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Brian O'Rourke Selected Research

Diamide

4/2010Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.
11/2008Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.
7/2007Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.

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Brian O'Rourke Research Topics

Disease

20Heart Failure
06/2022 - 02/2002
10Ischemia
01/2020 - 11/2002
5Cardiovascular Diseases (Cardiovascular Disease)
05/2022 - 11/2013
5Reperfusion Injury
05/2022 - 03/2004
5Inflammation (Inflammations)
12/2021 - 10/2003
5Mitochondrial Diseases (Mitochondrial Disease)
10/2019 - 07/2007
4Hypertrophy
01/2022 - 12/2008
3Neoplasms (Cancer)
05/2022 - 08/2010
3Obesity
11/2021 - 10/2019
3Insulin Resistance
11/2019 - 10/2015
3Cardiac Arrhythmias (Arrythmia)
03/2015 - 04/2010
3Infarction (Infarctions)
02/2013 - 05/2011
3Myocardial Infarction
11/2012 - 03/2003
2Atherosclerosis
05/2022 - 01/2020
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2022 - 02/2010
2Necrosis
01/2021 - 04/2012
2Cardiomyopathies (Cardiomyopathy)
10/2017 - 01/2016
2Fibrosis (Cirrhosis)
01/2016 - 06/2014
2Heart Diseases (Heart Disease)
03/2015 - 04/2011
2Hypoxia (Hypoxemia)
06/2011 - 08/2010
2Thrombosis (Thrombus)
01/2005 - 10/2003
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2022
1Cardiomegaly (Heart Hypertrophy)
05/2022
1Acute Kidney Injury (Acute Renal Failure)
12/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2021
1Abdominal Obesity
11/2021
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2021
1Fatigue
01/2021
1Flushing
01/2021
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021
1Coronary Disease (Coronary Heart Disease)
01/2020
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2020
1Atrial Fibrillation
01/2020
1Hyperglycemia
11/2019
1Weight Gain
10/2019
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
01/2018
1Cardiac Sudden Death (Sudden Cardiac Arrest)
01/2018
1Acquired Immunodeficiency Syndrome (AIDS)
01/2018
1Sepsis (Septicemia)
12/2017
1Atrial Remodeling
01/2017
1Left Ventricular Dysfunction
01/2016
1Diabetes Complications
01/2016
1Diabetic Cardiomyopathies
01/2016

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
01/2018 - 02/2002
6Adenosine Triphosphate (ATP)IBA
01/2022 - 11/2002
5Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 10/2009
4mitochondrial K(ATP) channelIBA
01/2020 - 11/2002
4CalciumIBA
01/2020 - 02/2002
4PotassiumIBA
10/2019 - 11/2002
3Mitochondrial DNA (mtDNA)IBA
01/2021 - 01/2020
3KATP ChannelsIBA
01/2020 - 11/2010
3Glucose (Dextrose)FDA LinkGeneric
10/2019 - 10/2015
3Glutathione (Reduced Glutathione)IBA
01/2015 - 11/2008
3NAD (NADH)IBA
12/2013 - 08/2008
3DiamideIBA
04/2010 - 07/2007
2Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
01/2022 - 12/2008
2Phenylephrine (Neo-Synephrine)FDA LinkGeneric
01/2021 - 12/2008
2DNA (Deoxyribonucleic Acid)IBA
01/2020 - 01/2020
2Fatty Acids (Saturated Fatty Acids)IBA
10/2019 - 10/2015
2ProteomeIBA
01/2018 - 01/2016
2SodiumIBA
03/2015 - 08/2004
1Brain-Derived Neurotrophic Factor (BDNF)IBA
06/2022
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
05/2022
1SulfurIBA
05/2022
1Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
01/2022
1Mitochondrial Form Creatine KinaseIBA
01/2022
1Isoproterenol (Isoprenaline)FDA LinkGeneric
01/2022
1Cyclic GMPIBA
11/2021
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
11/2021
1Peptides (Polypeptides)IBA
01/2021
1Vitamin A (Retinol)FDA LinkGeneric
01/2021
1Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2021
1R 115866IBA
01/2021
1calpastatinIBA
01/2021
1Therapeutic UsesIBA
01/2021
1RetinoidsIBA
01/2021
1Cyclophilin AIBA
01/2021
1Streptozocin (Streptozotocin)FDA Link
01/2020
1Potassium Channels (Potassium Channel)IBA
01/2020
1Metformin (Glucophage)FDA LinkGeneric
11/2019
1Hypoglycemic Agents (Hypoglycemics)IBA
11/2019
1IonsIBA
10/2019
1MyostatinIBA
10/2019
1Phosphotransferases (Kinase)IBA
01/2018
1salicylhydroxamic acid (SHAM)IBA
12/2017
1ConnexinsIBA
01/2017
1Pyruvic Acid (Pyruvate)IBA
01/2017
1Connexin 43 (Connexin43)IBA
01/2017
1AntioxidantsIBA
01/2017
1Insulin (Novolin)FDA Link
10/2015

Therapy/Procedure

9Therapeutics
11/2021 - 03/2009
3Cardiac Resynchronization Therapy
05/2015 - 03/2009
2Ligation
12/2017 - 05/2011
2Drug Therapy (Chemotherapy)
03/2015 - 08/2010
2Lasers (Laser)
01/2015 - 11/2008
1Hospice Care (Care, Bereavement)
05/2022
1Immunotherapy
12/2021
1Bioreactors (Bioreactor)
01/2021
1Punctures
12/2017
1Transplantation
10/2017